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text model · Qwen2.5 · macOS

Can I run Qwen2.5 72B on Apple M3 Ultra (256GB)?

Compatibility verdict VRAM threshold engine
Yes, it runsusable speed

Yes. Qwen2.5 72B runs on Apple M3 Ultra (256GB) at Q4_K_M (~50.2 GB of ~192 GB usable).

Needs ~50.2 GB Device usable ~192 GB

Runs at Q4_K_M using ~50.2 GB of ~192 GB usable. You have room for FP16 for higher quality.

Q4_K_M needed
~50.2 GB
Usable on device
~192 GB
Device memory
256 GB
Best quant
Q4_K_M

Run it

Install commands macOS

Pick your tool. All three load the same Q4_K_M weights.

Ollama
$ ollama run qwen2.5:72b
llama.cpp
$ llama-cli -hf bartowski/Qwen2.5-72B-Instruct-GGUF:Q4_K_M
LM Studio
$ lms get bartowski/Qwen2.5-72B-Instruct-GGUF

vLLM is NOT a Mac tool, it is a CUDA/Linux serving engine. Unified memory is not a fixed VRAM slice; ~70% is usable for weights.

Model Qwen2.5
Parameters
72B
Q4_K_M size
47.42 GB
Q8_0 size
77.26 GB
Context
128k
Ollama tag
qwen2.5:72b
Full Qwen2.5 72B requirements →
Device macOS
Memory
256 GB unified
Usable for weights
~192 GB
Best runtime
MLX direct / Ollama (MLX backend)
Best models for Apple M3 Ultra (256GB) →

You could also run

Run Qwen2.5 72B on other hardware

FAQ

Can Apple M3 Ultra (256GB) run Qwen2.5 72B?

Yes. Qwen2.5 72B runs on Apple M3 Ultra (256GB) at Q4_K_M (~50.2 GB of ~192 GB usable).

How much memory does Qwen2.5 72B need?

Apple M3 Ultra (256GB) has room to spare. At Q4_K_M the weights are ~47.42 GB; with KV cache and runtime overhead, budget ~50.2 GB at a 4k context.

What is the best tool to run Qwen2.5 72B on macOS?

LM Studio for a simple setup; mlx-lm for the most speed. vLLM is NOT a Mac tool, it is a CUDA/Linux serving engine. Unified memory is not a fixed VRAM slice; ~70% is usable for weights.

Sources

Memory figures are estimates. See methodology.